TruSight Oncology 500
Franklin allows for efficient integration with LIMS, EMR, and your own organization’s information system through an API, and also provides various ways to seamlessly import your data in bulk. You can easily upload batches of all raw data file formats from the BaseSpace App, as well as Amazon servers, other cloud-based sources, or your local computer directly through the platform’s UI.
Franklin has developed a dedicated and optimized variant detection pipeline for TSO 500 workflows, which is able to pick up all possible variant types on this assay. Franklin uses its own bioinformatic pipeline to identify SNPs and small insertions/deletions, combining GATK tools, DRAGEN, and dedicated indel callers, drawing on the most fitting algorithm for each step of the detection process. That way, the platform can identify artifacts and calling errors, increasing the accuracy of the overall calling results. For CNV detection, Rainbow, Franklin’s own proprietary algorithm, uses machine learning to identify amplifications and deletions.
TSO 500 allows you to analyze multiple variant types and key biomarkers in 500+ cancer-relevant genes across DNA and RNA in a single assay. For DNA, the analysis covers 523 genes (1.94 Mbp) and detects SNVs, indels, CNVs, tumor mutational burden (TMB), and microsatellite instability (MSI). If using the DNA + RNA bundle, you can also identify known and novel fusions (in 55 genes) and some splice variants (in 3 genes).
Franklin’s classification and prioritization engine leverages the power of AI to help pinpoint the relevant variants for your specific case, taking into account cancer type, updated FDA approvals and professional guidelines, recent publications, and clinical trials. Franklin presents information from more than 100 databases including prediction tools, normal population and somatic frequencies, and clinical repositories, and automatically classifies variants according to the latest AMP, ACMG, and Oncogenic guidelines. The platform works as a one-stop shop for genetic evidence, presenting all the relevant information from available sources, as well as Franklin Community data, all curated by our dedicated team of cancer specialists.
Franklin’s Report Studio helps you generate completely
customizable clinical reports without any added work. After
completing the case review, users can issue and even sign off a report that includes all relevant variants as well as their
interpretation and clinical evidence with the click of a button.
Customize a template that fits your needs, assign different roles to members of your team, and save lots of time and effort while ending up with a tailor-made report structure thoroughly designed for your organization’s specific workflow.
TruSight Oncology 500 covers key guidelines for multiple tumor types, such as lung, colon, and breast cancer, as well as sarcoma, melanoma, and others, and provides information regarding a wide range of cancer-related genes involved in clinical trials. These assays are becoming increasingly popular since they allow labs to unify wet lab workflows and simplify the experimental procedures for many cancer types, instead of having dedicated experiments for each specific biomarker.
However, the amount of data resulting from such a thorough panel can be overwhelmingly complex and translate into time-consuming dry lab processing. With Franklin, you can easily analyze TSO 500 cases to reach faster and more accurate results.
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Take advantage of the unique genetic dataset and curated information that Franklin Community has to offer
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